On April 4, 2017, the California Office of Administrative Law approved the revision of the maximum allowable dose level (MADL) for the California 65 inventory of ethylene glycol, with a maximum allowable dose level of 8700 μg per day.

The provision will take effect on July 1, 2017.

      According to the California 65 regulations, products that are placed on the California market must contain a warning if they contain substances in the California 65 list. California 65 itself does not set limits on hazardous substances, only safe harbor levels, Maximum Allowable Dose Level (MADL) MADL is one of the safe harbor indicators, products or emissions to drinking water There is no need to add a warning when the substance content is below this level. California regulations are more in compliance with existing cases. When individuals or groups question the safety of certain hazardous chemicals in a product and file a lawsuit, it will eventually reach a settlement agreement or a ruling result.
 
      Ethylene glycol, CAS No. 107-21-1, was added to the California 65 as a reproductive toxicant on June 19, 2015. Ethylene glycol, also known as glycol. Chemical formula HOCH2-CH2OH. Belong to the simplest diol. Colorless and odorless, sweet liquid, can be mixed with water in any ratio. Ethylene glycol is often used as an intermediate material for the synthesis of polyester compounds. It is also an antifreeze, deicing fluid, surface coating, heat transfer agent, industrial coolant, hydraulic oil, surfactant and emulsifier.